Transgenic expression of PML/RARalpha impairs myelopoiesis.
The translocation found in acute promyelocytic leukemia rearranges the promyelocytic leukemia gene (PML) on chromosome 15 with the retinoic acid receptor alpha (RARalpha) on chromosome 17. This yields a fusion transcript, PML/RARalpha, a transcription factor with reported dominant negative functions...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1996
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38846/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8755574/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.15.7900 |
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