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Transgenic expression of PML/RARalpha impairs myelopoiesis.

The translocation found in acute promyelocytic leukemia rearranges the promyelocytic leukemia gene (PML) on chromosome 15 with the retinoic acid receptor alpha (RARalpha) on chromosome 17. This yields a fusion transcript, PML/RARalpha, a transcription factor with reported dominant negative functions...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Early, E, Moore, M A, Kakizuka, A, Nason-Burchenal, K, Martin, P, Evans, R M, Dmitrovsky, E
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38846/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8755574/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.15.7900
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