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Synthesis of Quaternary α-Methyl α-Amino Acids by Asymmetric Alkylation of Pseudoephenamine Alaninamide Pivaldimine

[Image: see text] The utility of pseudoephenamine as a chiral auxiliary for the alkylative construction of quaternary α-methyl α-amino acids is demonstrated. The method is notable for the high diastereoselectivities of the alkylation reactions, for its versatility with respect to electrophilic subst...

詳細記述

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書誌詳細
主要な著者: Hugelshofer, Cedric L., Mellem, Kevin T., Myers, Andrew G.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3884032/
https://ncbi.nlm.nih.gov/pubmed/23746325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol401337p
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