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Synthesis of Quaternary α-Methyl α-Amino Acids by Asymmetric Alkylation of Pseudoephenamine Alaninamide Pivaldimine
[Image: see text] The utility of pseudoephenamine as a chiral auxiliary for the alkylative construction of quaternary α-methyl α-amino acids is demonstrated. The method is notable for the high diastereoselectivities of the alkylation reactions, for its versatility with respect to electrophilic subst...
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Main Authors: | , , |
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Format: | Artigo |
Language: | Inglês |
Published: |
2013
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Subjects: | |
Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3884032/ https://ncbi.nlm.nih.gov/pubmed/23746325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol401337p |
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