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Inactivation of TGF-β signaling and loss of PTEN cooperate to induce colon cancer in vivo
The accumulation of genetic and epigenetic alterations mediates colorectal cancer (CRC) formation by deregulating key signaling pathways in cancer cells. In CRC, one of the most commonly inactivated signaling pathways is the transforming growth factor-beta (TGF-β) signaling pathway, which is often i...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3883899/ https://ncbi.nlm.nih.gov/pubmed/23604118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.102 |
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