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TGF-β receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a β-catenin independent pathway
BACKGROUND & AIMS: During colorectal cancer pathogenesis, mutations and epigenetic events cause neoplastic behavior in epithelial cells by deregulating the Wnt, Ras–Raf–ERK, and transforming growth factor (TGF)-β signaling pathways, among others. The TGF-β signaling pathway is often inactivated...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2782436/ https://ncbi.nlm.nih.gov/pubmed/19208363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.01.066 |
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