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Telomerase Inhibitor Imetelstat (GRN163L) Limits the Lifespan of Human Pancreatic Cancer Cells

Telomerase is required for the unlimited lifespan of cancer cells. The vast majority of pancreatic adenocarcinomas overexpress telomerase activity and blocking telomerase could limit their lifespan. GRN163L (Imetelstat) is a lipid-conjugated N3′→P5′ thio-phosphoramidate oligonucleotide that blocks t...

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Bibliografiske detaljer
Main Authors: Burchett, Katrina M., Yan, Ying, Ouellette, Michel M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883701/
https://ncbi.nlm.nih.gov/pubmed/24409321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085155
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