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Imetelstat, a telomerase inhibitor, differentially affects normal and malignant megakaryopoiesis
Imetelstat (GRN163L) is a specific telomerase inhibitor that has demonstrated clinical activity in patients with myeloproliferative neoplasms (MPN) and in patients with solid tumors. The antitumor effects were associated with the development of thrombocytopenia, one of the common side effects observ...
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| Опубликовано в: : | Leukemia |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5985670/ https://ncbi.nlm.nih.gov/pubmed/28270692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.78 |
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