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Imetelstat, a telomerase inhibitor, differentially affects normal and malignant megakaryopoiesis

Imetelstat (GRN163L) is a specific telomerase inhibitor that has demonstrated clinical activity in patients with myeloproliferative neoplasms (MPN) and in patients with solid tumors. The antitumor effects were associated with the development of thrombocytopenia, one of the common side effects observ...

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Опубликовано в: :Leukemia
Главные авторы: Mosoyan, G, Kraus, T, Ye, F, Eng, K, Crispino, JD, Hoffman, R, Iancu-Rubin, C
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985670/
https://ncbi.nlm.nih.gov/pubmed/28270692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.78
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