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Factor VIIa binding to endothelial cell protein C receptor: Differences between mouse and human systems

Recent in vitro studies have shown that the zymogen and activated form of FVII bind to endothelial cell protein C receptor (EPCR). At present, there is no evidence that FVIIa binds to EPCR on vascular endothelium in vivo in the presence of circulating protein C, a primary ligand for EPCR. The presen...

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Autors principals: Sen, Prosenjit, Clark, Curtis A., Gopalakrishnan, Ramakrishnan, Hedner, Ulla, Esmon, Charles T., Pendurthi, Usha R., Rao, L. Vijaya Mohan
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883592/
https://ncbi.nlm.nih.gov/pubmed/22370814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH11-09-0672
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