Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection

Recent studies have shown that factor VIIa (FVIIa) binds to the endothelial cell protein C receptor (EPCR), a cellular receptor for protein C and activated protein C, but the physiologic significance of this interaction is unclear. In the present study, we show that FVIIa, upon binding to EPCR on en...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sen, Prosenjit, Gopalakrishnan, Ramakrishnan, Kothari, Hema, Keshava, Shiva, Clark, Curtis A., Esmon, Charles T., Pendurthi, Usha R., Rao, L. Vijaya Mohan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2011
Pynciau:
Thrombosis and Hemostasis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062318/
https://ncbi.nlm.nih.gov/pubmed/21252088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-310706
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