Loading...

Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection

Recent studies have shown that factor VIIa (FVIIa) binds to the endothelial cell protein C receptor (EPCR), a cellular receptor for protein C and activated protein C, but the physiologic significance of this interaction is unclear. In the present study, we show that FVIIa, upon binding to EPCR on en...

Full description

Saved in:
Bibliographic Details
Main Authors: Sen, Prosenjit, Gopalakrishnan, Ramakrishnan, Kothari, Hema, Keshava, Shiva, Clark, Curtis A., Esmon, Charles T., Pendurthi, Usha R., Rao, L. Vijaya Mohan
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062318/
https://ncbi.nlm.nih.gov/pubmed/21252088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-310706
Tags: Add Tag
No Tags, Be the first to tag this record!