Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection

Recent studies have shown that factor VIIa (FVIIa) binds to the endothelial cell protein C receptor (EPCR), a cellular receptor for protein C and activated protein C, but the physiologic significance of this interaction is unclear. In the present study, we show that FVIIa, upon binding to EPCR on en...

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Bibliographic Details
Main Authors: Sen, Prosenjit, Gopalakrishnan, Ramakrishnan, Kothari, Hema, Keshava, Shiva, Clark, Curtis A., Esmon, Charles T., Pendurthi, Usha R., Rao, L. Vijaya Mohan
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Thrombosis and Hemostasis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062318/
https://ncbi.nlm.nih.gov/pubmed/21252088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-310706
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