The Role of Inherited TPMT and COMT Genetic Variation in Cisplatin-induced Ototoxicity in Children with Cancer

Ototoxicity is a debilitating side effect of platinating agents with substantial inter-patient variability. We sought to evaluate the association of TPMT and COMT genetic variations with cisplatin-related hearing damage in the context of frontline pediatric cancer treatment protocols. In 213 childre...

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Main Authors: Yang, Jun J., Lim, Joshua Yew-Suang, Huang, Jie, Bass, Johnnie, Wu, Jianrong, Wang, Chong, Fang, Jie, Stewart, Elizabeth, Harstead, Elaine H., Shuyu, E, Robinson, Giles W., Evans, William E., Pappo, Alberto, Zuo, Jian, Relling, Mary V., Onar-Thomas, Arzu, Gajjar, Amar, Stewart, Clinton F.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883563/
https://ncbi.nlm.nih.gov/pubmed/23820299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2013.121
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