Common Variants in ACYP2 Influence Susceptibility to Cisplatin-induced Hearing Loss

Taking a genome-wide association study approach, we identified inherited genetic variations in ACYP2 associated with cisplatin ototoxicity (rs1872328, P = 3.9×10(-8), hazard ratio = 4.5) in 238 children with newly-diagnosed brain tumors, with independent replication in 68 similarly treated children....

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Xu, Heng, Robinson, Giles W., Huang, Jie, Lim, Joshua Yew-Suang, Zhang, Hui, Bass, Johnnie K., Broniscer, Alberto, Chintagumpala, Murali, Bartels, Ute, Gururangan, Sri, Hassall, Tim, Fisher, Michael, Cohn, Richard, Yamashita, Tetsuji, Teitz, Tal, Zuo, Jian, Onar-Thomas, Arzu, Gajjar, Amar, Stewart, Clinton F., Yang, Jun J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358157/
https://ncbi.nlm.nih.gov/pubmed/25665007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3217
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