Paradoxical activation of T cells via augmented ERK signaling mediated by a RAF inhibitor

RAF inhibitors selectively block ERK signaling in BRAF-mutant melanomas and have defined a genotype-guided approach to care for this disease. RAF inhibitors have the opposite effect in BRAF wild-type tumor cells, where they cause hyperactivation of ERK signaling. Here, we predict that RAF inhibitors...

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Main Authors: Callahan, Margaret K., Masters, Gregg, Pratilas, Christine A., Ariyan, Charlotte, Katz, Jessica, Kitano, Shigehisa, Russell, Valerie, Gordon, Ruth Ann, Vyas, Shachi, Yuan, Jianda, Gupta, Ashok, Wigginton, Jon M., Rosen, Neal, Merghoub, Taha, Jure-Kunkel, Maria, Wolchok, Jedd D.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883307/
https://ncbi.nlm.nih.gov/pubmed/24416731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0160
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