Paradoxical activation of T cells via augmented ERK signaling mediated by a RAF inhibitor

RAF inhibitors selectively block ERK signaling in BRAF-mutant melanomas and have defined a genotype-guided approach to care for this disease. RAF inhibitors have the opposite effect in BRAF wild-type tumor cells, where they cause hyperactivation of ERK signaling. Here, we predict that RAF inhibitors...

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Autores principales: Callahan, Margaret K., Masters, Gregg, Pratilas, Christine A., Ariyan, Charlotte, Katz, Jessica, Kitano, Shigehisa, Russell, Valerie, Gordon, Ruth Ann, Vyas, Shachi, Yuan, Jianda, Gupta, Ashok, Wigginton, Jon M., Rosen, Neal, Merghoub, Taha, Jure-Kunkel, Maria, Wolchok, Jedd D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883307/
https://ncbi.nlm.nih.gov/pubmed/24416731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0160
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