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Hydrogen Exchange – Mass Spectrometry Measures Stapled Peptide Conformational Dynamics and Predicts Pharmacokinetic Properties
Peptide drugs have traditionally suffered from poor pharmacokinetic properties due to their conformational flexibility and the interaction of proteases with backbone amide bonds. “Stapled Peptides” are cyclized using an all-hydrocarbon cross-linking strategy to reinforce their α-helical conformation...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3883098/ https://ncbi.nlm.nih.gov/pubmed/24215480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac403173p |
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