Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

Mammalian cells can generate ATP via glycolysis or mitochondrial respiration. Oncogene activation and hypoxia promote glycolysis and lactate secretion. The significance of these metabolic changes to ATP production remains however ill defined. Here, we integrate LC-MS-based isotope tracer studies wit...

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Main Authors: Fan, Jing, Kamphorst, Jurre J, Mathew, Robin, Chung, Michelle K, White, Eileen, Shlomi, Tomer, Rabinowitz, Joshua D
Formato: Artigo
Idioma:Inglês
Publicado: European Molecular Biology Organization 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882799/
https://ncbi.nlm.nih.gov/pubmed/24301801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2013.65
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