ENU mutation mapped to a distal region of chromosome 11 is a major determinant of bone size

Using a phenotype driven n-ethyl-nitrosourea (ENU) screen in growth hormone-deficient mice, we have identified a mutant (named 14104) that exhibited a smaller bone size. Phenotype measurements by microcomputed tomography revealed that mutant mice exhibited a 43 and 34% reduction in tissue area and b...

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Detalhes bibliográficos
Main Authors: Edderkaoui, Bouchra, Kesavan, Chandrasekhar, Baylink, David J., Wergedal, Jon E., Srivastava, Apurva K., Mohan, Subburaman
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Molecular Genetics of Complex Traits
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882684/
https://ncbi.nlm.nih.gov/pubmed/24151243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00142.2013
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