An Integrated Mitochondrial ROS Production and Scavenging Model: Implications for Heart Failure

It has been observed experimentally that cells from failing hearts exhibit elevated levels of reactive oxygen species (ROS) upon increases in energetic workload. One proposed mechanism for this behavior is mitochondrial Ca(2+) mismanagement that leads to depletion of ROS scavengers. Here, we present...

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Autores principales: Gauthier, Laura D., Greenstein, Joseph L., O’Rourke, Brian, Winslow, Raimond L.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2013
Materias:
Systems Biophysics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882515/
https://ncbi.nlm.nih.gov/pubmed/24359755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.11.007
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