A Computational Model of Reactive Oxygen Species and Redox Balance in Cardiac Mitochondria

Elevated levels of reactive oxygen species (ROS) play a critical role in cardiac myocyte signaling in both healthy and diseased cells. Mitochondria represent the predominant cellular source of ROS, specifically the activity of complexes I and III. The model presented here explores the modulation of...

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Detalhes bibliográficos
Main Authors: Gauthier, Laura D., Greenstein, Joseph L., Cortassa, Sonia, O’Rourke, Brian, Winslow, Raimond L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Systems Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752118/
https://ncbi.nlm.nih.gov/pubmed/23972856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.07.006
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