Mitochondrial Energetics, pH Regulation, and Ion Dynamics: A Computational-Experimental Approach

We developed a computational model of mitochondrial energetics that includes Ca(2+), proton, Na(+), and phosphate dynamics. The model accounts for distinct respiratory fluxes from substrates of complex I and complex II, pH effects on equilibrium constants and enzyme kinetics, and the acid-base equil...

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Detalhes bibliográficos
Main Authors: Wei, An-Chi, Aon, Miguel A., O'Rourke, Brian, Winslow, Raimond L., Cortassa, Sonia
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2011
Assuntos:
Cellular Biophysics and Electrophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123977/
https://ncbi.nlm.nih.gov/pubmed/21689522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.05.027
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