Model Inspired by Nuclear Pore Complex Suggests Possible Roles for Nuclear Transport Receptors in Determining Its Structure

Nuclear transport receptors (NTRs) mediate nucleocytoplasmic transport via their affinity for unstructured proteins (polymers) in the nuclear pore complex (NPC). Here, we have modeled the effect of NTRs on polymeric structure in the nanopore confinement of the NPC central conduit. The model explicit...

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Hlavní autoři: Osmanović, Dino, Ford, Ian J., Hoogenboom, Bart W.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2013
Témata:
Molecular Machines, Motors and Nanoscale Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882460/
https://ncbi.nlm.nih.gov/pubmed/24359750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.11.013
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