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The Three-State Model: A Minimal Allosteric Description of Homotropic and Heterotropic Effects in the Binding of Ligands to Hemoglobin

The effect of hydrogen ion, chloride, and 2,3-diphosphoglycerate upon the oxygen binding of hemoglobin may be satisfactorily described by an allosteric model employing three affinity states. The allosteric two-state model does not provide even an approximate description except under defined extreme...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Minton, Allen P., Imai, Kiyohiro
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1974
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC388240/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4364537/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.4.1418
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