Organic anion transporting polypeptide 1B transporters modulate hydroxyurea pharmacokinetics

Hydroxyurea is currently the only FDA-approved drug that ameliorates the pathophysiology of sickle cell anemia. Unfortunately, substantial interpatient variability in the pharmacokinetics (PK) of hydroxyurea may result in variation of the drug's efficacy. However, little is known about mechanis...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Walker, Aisha L., Lancaster, Cynthia S., Finkelstein, David, Ware, Russell E., Sparreboom, Alex
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2013
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882360/
https://ncbi.nlm.nih.gov/pubmed/23986199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00232.2013
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