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Organic anion transporting polypeptide 1B transporters modulate hydroxyurea pharmacokinetics

Hydroxyurea is currently the only FDA-approved drug that ameliorates the pathophysiology of sickle cell anemia. Unfortunately, substantial interpatient variability in the pharmacokinetics (PK) of hydroxyurea may result in variation of the drug's efficacy. However, little is known about mechanis...

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Главные авторы: Walker, Aisha L., Lancaster, Cynthia S., Finkelstein, David, Ware, Russell E., Sparreboom, Alex
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882360/
https://ncbi.nlm.nih.gov/pubmed/23986199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00232.2013
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