Geometric and Electronic Structure of the Mn(IV)Fe(III) Cofactor in Class Ic Ribonucleotide Reductase: Correlation to the Class Ia Binuclear Non-Heme Iron Enzyme

The class Ic ribonucleotide reductase (RNR) from Chlamydia trachomatis (Ct) utilizes a Mn/Fe hetero-binuclear cofactor, rather than the Fe/Fe cofactor found in the β (R2) subunit of the class Ia enzymes, to react with O(2). This reaction produces a stable Mn(IV)Fe(III) cofactor that initiates a radi...

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Auteurs principaux: Kwak, Yeonju, Jiang, Wei, Dassama, Laura M.K., Park, Kiyoung, Bell, Caleb B., Liu, Lei V., Wong, Shaun D., Saito, Makina, Kobayashi, Yasuhiro, Kitao, Shinji, Seto, Makoto, Yoda, Yoshitaka, Alp, E. Ercan, Zhao, Jiyong, Bollinger, J Martin, Krebs, Carsten, Solomon, Edward I.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882272/
https://ncbi.nlm.nih.gov/pubmed/24131208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja409510d
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