Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer

PURPOSE: SCLC is an aggressive malignancy affecting nearly 30,000 people annually in the United States. We have previously identified elevated PARP1 levels in SCLC and demonstrated in vitro sensitivity to the PARP inhibitors AZD 2281 and AG014699. Here, we evaluate activity of a novel, potent PARP i...

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Hauptverfasser: Cardnell, Robert, J, Feng, Ying, Diao, Lixia, Fan, You-Hong, Masrorpour, Fatemah, Wang, Jing, Shen, Yuqiao, Mills, Gordon, B, Minna, John, D, Heymach, John, V, Byers, Lauren, A
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882158/
https://ncbi.nlm.nih.gov/pubmed/24077350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1975
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