Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer

Small cell lung cancer (SCLC) is an aggressive malignancy with limited treatment options. We previously found that PARP is overexpressed in SCLC and that targeting PARP reduces cell line and tumor growth in preclinical models. However, SCLC cell lines with PI3K/mTOR pathway activation were relativel...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cardnell, Robert J., Feng, Ying, Mukherjee, Seema, Diao, Lixia, Tong, Pan, Stewart, C. Allison, Masrorpour, Fatemeh, Fan, YouHong, Nilsson, Monique, Shen, Yuqiao, Heymach, John V., Wang, Jing, Byers, Lauren A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824499/
https://ncbi.nlm.nih.gov/pubmed/27055253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152584
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