Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer

Small cell lung cancer (SCLC) is an aggressive malignancy with limited treatment options. We previously found that PARP is overexpressed in SCLC and that targeting PARP reduces cell line and tumor growth in preclinical models. However, SCLC cell lines with PI3K/mTOR pathway activation were relativel...

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Opis bibliograficzny
Wydane w:PLoS One
Główni autorzy: Cardnell, Robert J., Feng, Ying, Mukherjee, Seema, Diao, Lixia, Tong, Pan, Stewart, C. Allison, Masrorpour, Fatemeh, Fan, YouHong, Nilsson, Monique, Shen, Yuqiao, Heymach, John V., Wang, Jing, Byers, Lauren A.
Format: Artigo
Język:Inglês
Wydane: Public Library of Science 2016
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824499/
https://ncbi.nlm.nih.gov/pubmed/27055253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152584
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