A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo therapeutic screening

Mutations in the superoxide dismutase gene (SOD1) are one cause of familial amyotrophic lateral sclerosis [ALS; also known as motor neuron disease (MND)] in humans. ALS is a relentlessly progressive neurodegenerative disease and, to date, there are no neuroprotective therapies with significant impac...

詳細記述

保存先:
書誌詳細
主要な著者: Da Costa, Marc M. J., Allen, Claire E., Higginbottom, Adrian, Ramesh, Tennore, Shaw, Pamela J., McDermott, Christopher J.
フォーマット: Artigo
言語:Inglês
出版事項: The Company of Biologists Limited 2014
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882050/
https://ncbi.nlm.nih.gov/pubmed/24092880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.012013
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