Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a lethal muscle-wasting disease. Studies in Drosophila showed that genetic increase of the levels of the bioactive sphingolipid sphingosine-1-phosphate (S1P) or delivery of 2-acetyl-5-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, suppresses dystrophi...

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Bibliographic Details
Main Authors: Nguyen-Tran, Diem-Hang, Hait, Nitai C., Sperber, Henrik, Qi, Junlin, Fischer, Karin, Ieronimakis, Nick, Pantoja, Mario, Hays, Aislinn, Allegood, Jeremy, Reyes, Morayma, Spiegel, Sarah, Ruohola-Baker, Hannele
Format: Artigo
Language:Inglês
Published: The Company of Biologists Limited 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882047/
https://ncbi.nlm.nih.gov/pubmed/24077965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.013631
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