STING Recognition of Cytoplasmic DNA Instigates Cellular Defense

How the cell recognizes cytosolic DNA including DNA based microbes to trigger host defense related gene activation remains to be fully resolved. Here, we demonstrate that STING (for Stimulator of Interferon Genes), an endoplasmic reticulum (ER) translocon associated transmembrane protein, acts to de...

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Détails bibliographiques
Auteurs principaux: Abe, Takayuki, Harashima, Ai, Xia, Tianli, Konno, Hiroyasu, Konno, Keiko, Morales, Alejo, Ahn, Jeonghyun, Gutman, Delia, Barber, Glen N.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3881179/
https://ncbi.nlm.nih.gov/pubmed/23478444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.01.039
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