Efficient siRNA transfection to the inner ear through the intact round window by a novel proteidic delivery technology in the chinchilla

The use of small-interfering RNA (siRNA) has great potential for the development of drugs designed to knock down the expression of damage- or disease-causing genes. However, because of the high molecular weight and negative charge of siRNA, it is restricted from crossing the blood–cochlear barrier,...

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Detalhes bibliográficos
Main Authors: Qi, W, Ding, D, Zhu, H, Lu, D, Wang, Y, Ding, J, Yan, W, Jia, M, Guo, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3881030/
https://ncbi.nlm.nih.gov/pubmed/24108151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2013.49
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