Kinetic and Thermodynamic Rationale for SAHA Being a Preferential Human HDAC8 Inhibitor as Compared to the Structurally Similar Ligand, TSA

Of the different hydroxamate-based histone deacetylase (HDAC) inhibitors, Suberoylanilide hydroxamic acid (SAHA) has been approved by the FDA for treatment of T-cell lymphoma. Interestingly, a structurally similar inhibitor, Trichostatin A (TSA), which has a higher in vitro inhibitory-potency agains...

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Detalhes bibliográficos
Main Authors: Singh, Raushan K., Lall, Naveena, Leedahl, Travis S., McGillivray, Abigail, Mandal, Tanmay, Haldar, Manas, Mallik, Sanku, Cook, Gregory, Srivastava, D.K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880809/
https://ncbi.nlm.nih.gov/pubmed/24079912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400740x
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