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Using genetic methods to define the targets of compounds with antimalarial activity

Although phenotypic cellular screening has been used to drive antimalarial drug discovery in recent years, in some cases target-based drug discovery remains more attractive. This is especially true when appropriate high-throughput cellular assays are lacking, as is the case for drug discovery effort...

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Detalhes bibliográficos
Main Authors: Flannery, Erika L., Fidock, David A., Winzeler, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880619/
https://ncbi.nlm.nih.gov/pubmed/23927658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400325j
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