Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B

Hepatitis C virus (HCV) is a major global public health problem. While the current standard of care, a direct-acting antiviral (DAA) protease inhibitor taken in combination with pegylated interferon and ribavirin, represents a major advancement in recent years, an unmet medical need still exists for...

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Main Authors: Schoenfeld, Ryan C., Bourdet, David L., Brameld, Ken A., Chin, Elbert, de Vicente, Javier, Fung, Amy, Harris, Seth F., Lee, Eun K., Pogam, Sophie Le, Leveque, Vincent, Li, Jim, Lui, Alfred S-T., Najera, Isabel, Rajyaguru, Sonal, Sangi, Michael, Steiner, Sandra, Talamas, Francisco X., Taygerly, Joshua P., Zhao, Junping
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880614/
https://ncbi.nlm.nih.gov/pubmed/24069953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401266k
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