Curcumin Chemosensitizes 5-Fluorouracil Resistant MMR-Deficient Human Colon Cancer Cells in High Density Cultures

OBJECTIVE: Treatment of colorectal cancer (CRC) remains a clinical challenge, as more than 15% of patients are resistant to 5-Fluorouracil (5-FU)-based chemotherapeutic regimens, and tumor recurrence rates can be as high as 50–60%. Cancer stem cells (CSC) are capable of surviving conventional chemot...

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Autori principali: Shakibaei, Mehdi, Buhrmann, Constanze, Kraehe, Patricia, Shayan, Parviz, Lueders, Cora, Goel, Ajay
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880338/
https://ncbi.nlm.nih.gov/pubmed/24404205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085397
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