A Randomized Phase II Study of Cilengitide (EMD 121974) in Patients with Metastatic Melanoma

Cilengitide (EMD121974) is a selective inhibitor of integrins α(v)β(3) and α(v)β(5). The α(v)β(3) promotes the proliferation of tumor-associated endothelial cells and potentially the survival of melanoma cells. We conducted a randomized phase II trial in patients with metastatic melanoma to evaluate...

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Hlavní autoři: Kim, Kevin B., Prieto, Victor, Joseph, Richard W., Diwan, Abdul H., Gallick, Gary E., Papadopoulos, Nicholas E., Bedikian, Agop Y., Camacho, Luis H., Hwu, Patrick, Ng, Chaan S., Wei, Wei, Johnson, Marcella M., Wittemer, Sabine M., Vardeleon, Anna, Reckeweg, Aaron, Colevas, A. Dimitrios
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880198/
https://ncbi.nlm.nih.gov/pubmed/22668797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CMR.0b013e32835312e4
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