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Modular Isoquinoline Synthesis Using Catalytic Enolate Arylation and in Situ Functionalization
[Image: see text] A methyl ketone, an aryl bromide, an electrophile, and ammonium chloride were combined in a four-component, three-step, and one-pot coupling procedure to furnish substituted isoquinolines in overall yields of up to 80%. This protocol utilizes the palladium catalyzed α-arylation rea...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3880054/ https://ncbi.nlm.nih.gov/pubmed/24251885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol4030309 |
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