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Toward an Understanding of Agonist Binding to Human Orexin-1 and Orexin-2 Receptors with G-Protein-Coupled Receptor Modeling and Site-Directed Mutagenesis
[Image: see text] The class A G-protein-coupled receptors (GPCRs) Orexin-1 (OX1) and Orexin-2 (OX2) are located predominantly in the brain and are linked to a range of different physiological functions, including the control of feeding, energy metabolism, modulation of neuro-endocrine function, and...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American
Chemical Society
2013
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3880013/ https://ncbi.nlm.nih.gov/pubmed/24144388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401119m |
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