Antenatal Allopurinol Reduces Hippocampal Brain Damage After Acute Birth Asphyxia in Late Gestation Fetal Sheep

Free radical–induced reperfusion injury is a recognized cause of brain damage in the newborn after birth asphyxia. The xanthine oxidase inhibitor allopurinol reduces free radical synthesis and crosses the placenta easily. Therefore, allopurinol is a promising therapeutic candidate. This study tested...

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Main Authors: Kaandorp, Joepe J., Derks, Jan B., Oudijk, Martijn A., Torrance, Helen L., Harmsen, Marline G., Nikkels, Peter G. J., van Bel, Frank, Visser, Gerard H. A., Giussani, Dino A.
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2014
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879995/
https://ncbi.nlm.nih.gov/pubmed/23793473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1933719113493516
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