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Maternal-to-fetal allopurinol transfer and xanthine oxidase suppression in the late gestation pregnant rat

Fetal brain hypoxic injury remains a concern in high-risk delivery. There is significant clinical interest in agents that may diminish neuronal damage during birth asphyxia, such as in allopurinol, an inhibitor of the prooxidant enzyme xanthine oxidase. Here, we established in a rodent model the cap...

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Detalhes bibliográficos
Main Authors: Kane, Andrew D, Camm, Emily J, Richter, Hans G, Lusby, Ciara, Tijsseling, Deodata, Kaandorp, Joepe J, Derks, Jan B, Ozanne, Susan E, Giussani, Dino A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871471/
https://ncbi.nlm.nih.gov/pubmed/24400158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/phy2.156
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