Recapitulation of Pancreatic Neuroendocrine Tumors in Human Multiple Endocrine Neoplasia Type I (MEN1) Syndrome via Pdx1-directed Inactivation of Men1

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal syndrome caused by mutations in the MEN1 tumor suppressor gene. While the protein product of MEN1, menin, is ubiquitously expressed, somatic loss of the remaining wildtype MEN1 allele results in tumors primarily in parathyroid, pituitary, an...

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Hauptverfasser: Shen, H.-C. Jennifer, He, Mei, Powell, Anathea, Adem, Asha, Lorang, Dominique, Heller, Charles, Grover, Amelia C., Ylaya, Kris, Hewitt, Stephen M., Marx, Stephen J., Spiegel, Allen M., Libutti, Steven K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879686/
https://ncbi.nlm.nih.gov/pubmed/19208834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3662
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