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CD4 and BST-2/Tetherin Proteins Retro-translocate from Endoplasmic Reticulum to Cytosol as Partially Folded and Multimeric Molecules

CD4 and BST-2/Tetherin are cellular membrane proteins targeted to degradation by the HIV-1 protein Vpu. In both cases proteasomal degradation following recruitment into the ERAD pathway has been described. CD4 is a type I transmembrane glycoprotein, with four extracellular immunoglobulin-like domain...

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Bibliografski detalji
Glavni autori: Petris, Gianluca, Casini, Antonio, Sasset, Linda, Cesaratto, Francesca, Bestagno, Marco, Cereseto, Anna, Burrone, Oscar R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879533/
https://ncbi.nlm.nih.gov/pubmed/24257748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.512368
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