Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

Chronic (5-16 hr) exposure of cultured human lymphocytes to 10(-8) M insulin at 37° in vitro produced a decrease in insulin receptor concentrations unaccounted for by simple occupancy of sites; acute exposure (0-2 hr) was without effect. These results reproduced observations in vivo where chronic hy...

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Main Authors: Gavin, James R., Roth, Jesse, Neville, David M., De Meyts, Pierre, Buell, Donald N.
Format: Artigo
Jezik:Inglês
Izdano: 1974
Teme:
Biological Sciences: Biochemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC387937/
https://ncbi.nlm.nih.gov/pubmed/4359334
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