Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

Chronic (5-16 hr) exposure of cultured human lymphocytes to 10(-8) M insulin at 37° in vitro produced a decrease in insulin receptor concentrations unaccounted for by simple occupancy of sites; acute exposure (0-2 hr) was without effect. These results reproduced observations in vivo where chronic hy...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Gavin, James R., Roth, Jesse, Neville, David M., De Meyts, Pierre, Buell, Donald N.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1974
Soggetti:	Biological Sciences: Biochemistry
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC387937/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4359334/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.1.84
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