Group B Streptococcus Engages an Inhibitory Siglec through Sialic Acid Mimicry to Blunt Innate Immune and Inflammatory Responses In Vivo

Group B Streptococcus (GBS) is a common agent of bacterial sepsis and meningitis in newborns. The GBS surface capsule contains sialic acids (Sia) that engage Sia-binding immunoglobulin-like lectins (Siglecs) on leukocytes. Here we use mice lacking Siglec-E, an inhibitory Siglec of myelomonocytic cel...

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Detalhes bibliográficos
Main Authors: Chang, Yung-Chi, Olson, Joshua, Beasley, Federico C., Tung, Christine, Zhang, Jiquan, Crocker, Paul R., Varki, Ajit, Nizet, Victor
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879367/
https://ncbi.nlm.nih.gov/pubmed/24391502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003846
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