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Mechanism of Inhibition of Eukaryotic Protein Synthesis by Trichothecene Fungal Toxins
The 12,13-epoxytrichothecenes, a group of sesquiterpenoid fungal antibiotics, inhibit protein synthesis in eukaryotic cells but do not share a common mode of action. Trichodermin stabilizes polyribosomes, prevents their disaggregation by puromycin, and also prevents the release of nascent peptides f...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1974
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC387925/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4521056/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.1.30 |
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