NCYM, a Cis-Antisense Gene of MYCN, Encodes a De Novo Evolved Protein That Inhibits GSK3β Resulting in the Stabilization of MYCN in Human Neuroblastomas

The rearrangement of pre-existing genes has long been thought of as the major mode of new gene generation. Recently, de novo gene birth from non-genic DNA was found to be an alternative mechanism to generate novel protein-coding genes. However, its functional role in human disease remains largely un...

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Main Authors: Suenaga, Yusuke, Islam, S. M. Rafiqul, Alagu, Jennifer, Kaneko, Yoshiki, Kato, Mamoru, Tanaka, Yukichi, Kawana, Hidetada, Hossain, Shamim, Matsumoto, Daisuke, Yamamoto, Mami, Shoji, Wataru, Itami, Makiko, Shibata, Tatsuhiro, Nakamura, Yohko, Ohira, Miki, Haraguchi, Seiki, Takatori, Atsushi, Nakagawara, Akira
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879166/
https://ncbi.nlm.nih.gov/pubmed/24391509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003996
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