Lifespan Extension Conferred by Endoplasmic Reticulum Secretory Pathway Deficiency Requires Induction of the Unfolded Protein Response

Cells respond to accumulation of misfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR) signaling pathway. The UPR restores ER homeostasis by degrading misfolded proteins, inhibiting translation, and increasing expression of chaperones that enhance ER...

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Hauptverfasser: Labunskyy, Vyacheslav M., Gerashchenko, Maxim V., Delaney, Joe R., Kaya, Alaattin, Kennedy, Brian K., Kaeberlein, Matt, Gladyshev, Vadim N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879150/
https://ncbi.nlm.nih.gov/pubmed/24391512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004019
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