Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing

Single-molecule real-time (SMRT) DNA sequencing allows the systematic detection of chemical modifications such as methylation but has not previously been applied on a genome-wide scale. We used this approach to detect 49,311 putative 6-methyladenine (m6A) residues and 1,407 putative 5-methylcytosine...

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Autori principali: Fang, Gang, Munera, Diana, Friedman, David I, Mandlik, Anjali, Chao, Michael C, Banerjee, Onureena, Feng, Zhixing, Losic, Bojan, Mahajan, Milind C, Jabado, Omar J, Deikus, Gintaras, Clark, Tyson A, Luong, Khai, Murray, Iain A, Davis, Brigid M, Keren-Paz, Alona, Chess, Andrew, Roberts, Richard J, Korlach, Jonas, Turner, Steve W, Kumar, Vipin, Waldor, Matthew K, Schadt, Eric E
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879109/
https://ncbi.nlm.nih.gov/pubmed/23138224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2432
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