Suppression of autophagy enhances preferential toxicity of paclitaxel to folliculin-deficient renal cancer cells

BACKGROUND: Paclitaxel, a widely used chemotherapeutic drug, can induce apoptosis in variety of cancer cells. A previous study has shown preferential toxicity of paclitaxel to FLCN-deficient kidney cancer cell line, UOK257. In this report, we investigate the cellular and molecular mechanism of pacli...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhang, Qi, Si, Shuhui, Schoen, Sue, Chen, Jindong, Jin, Xun-Bo, Wu, Guan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2013
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879005/
https://ncbi.nlm.nih.gov/pubmed/24305604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-32-99
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